Glaesserella parasuis infection disrupts the gut–lung axis via microbiota dysbiosis and metabolic reprogramming leading to intestinal barrier impairment in piglets
This study demonstrates that <i>G. parasuis</i> infection extensively remodels the gut-lung axis microbiota and host metabolome, leading to intestinal barrier impairment. The perturbation of arginine biosynthesis may compromise host immunity. These results provide novel mechanistic insights into the pathogenesis of Glässer's disease.
Authors
- Xinlu Sun (ORCID: https://orcid.org/0000-0002-8776-3400)
- Xiaohu Liu (ORCID: https://orcid.org/0000-0002-8973-438X)
- Menglu Li (ORCID: https://orcid.org/0009-0008-9945-8762)
- Ronghuan Yin
- Meiling Qian
- Yuanyuan Zhou
- Na Li
- Fanhua Zeng
- Ronglan Yin
- Ying Guo
- Aobo Shen
- Haoran Wang
Institutions
- Shenyang Agricultural University (CN)
- Jilin University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fcimb.2026.1740531
- Primary Topic
- Microbial infections and disease research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province
- Shenyang Agricultural University