How to Analyze Longitudinal Patient‐Reported Outcomes in Populations With High Mortality Rates

The interpretation of longitudinal PROs strongly depends on the chosen method, associated estimands and how patients that died are addressed: different methods lead to different estimates and conclusions. Properly defining the research question and choosing the most appropriate method is essential for meaningful interpretations for clinicians and patients.

Authors

N. de Glas
Joosje C. Baltussen (ORCID: https://orcid.org/0000-0001-8635-2581)
Johanneke E. A. Portielje (ORCID: https://orcid.org/0000-0002-0246-1631)
Stella Trompet
Frederiek van den Bos
Saskia le Cessie

Institutions

Leiden University Medical Center (NL)
3T Helse (Norway) (NO)

Publication Details

Journal: Journal of the American Geriatrics Society
Published: 2026-02-05
DOI: https://doi.org/10.1111/jgs.70327
Primary Topic: Cancer survivorship and care
Type: article
Field-Weighted Citation Impact: 0.00

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article

How to Analyze Longitudinal Patient‐Reported Outcomes in Populations With High Mortality Rates

N. de Glas, Joosje C. Baltussen, Johanneke E. A. Portielje, Stella Trompet et al.

Feb 5, 2026

Journal of the American Geriatrics Society

Cancer survivorship and care

article

How to Analyze Longitudinal Patient‐Reported Outcomes in Populations With High Mortality Rates

N. de Glas, Joosje C. Baltussen, Johanneke E. A. Portielje, Stella Trompet, Frederiek van den Bos, Saskia le Cessie

February 5, 2026article en

Abstract

The interpretation of longitudinal PROs strongly depends on the chosen method, associated estimands and how patients that died are addressed: different methods lead to different estimates and conclusions. Properly defining the research question and choosing the most appropriate method is essential for meaningful interpretations for clinicians and patients.

Journal of the American Geriatrics Society

Leiden University Medical Center (NL), 3T Helse (Norway) (NO)

Good health and well-being

Openalex Percentile: Top 65%

Cancer survivorship and care

DOI Open Access PDF OpenAlex

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