Insomnia-Related Metabolomic Profiles Reflect Antioxidant Deficits and Relate to Cognitive Decline Through a Metabolic Risk Score in HCHS/SOL

The metabolomic profile associated with insomnia symptoms encompasses diet and gut microbiome metabolites. This study identified specific metabolites linked to insomnia that are also related to comorbidities, such as a higher risk of developing MCI during follow-up, suggesting a shared mechanism.

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Publication Details

Journal
medRxiv
Published
2026-02-05
DOI
https://doi.org/10.64898/2026.02.04.26345594
Primary Topic
Sleep and related disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Insomnia-Related Metabolomic Profiles Reflect Antioxidant Deficits and Relate to Cognitive Decline Through a Metabolic Risk Score in HCHS/SOL

Cynthia Kusters, QIBIN QI, Ying Zhang, T. Sofer et al.
medRxiv
Sleep and related disorders
article

Insomnia-Related Metabolomic Profiles Reflect Antioxidant Deficits and Relate to Cognitive Decline Through a Metabolic Risk Score in HCHS/SOL

Cynthia Kusters, QIBIN QI, Ying Zhang, T. Sofer, Jose Santos Cabrera, Carmen R. Isasi, S. Redline, Alberto R. DJ Ramos, Bing Yu, Phyllis C Zee, Yu Zhang, Raanan Arens, Joon Chung, Carmela Alcantara, Hector M Gonzalez, Krista M Perreira, Wassim Tarraf, Tianyi Huang, Martha L. Daviglus
article en

Abstract

The metabolomic profile associated with insomnia symptoms encompasses diet and gut microbiome metabolites. This study identified specific metabolites linked to insomnia that are also related to comorbidities, such as a higher risk of developing MCI during follow-up, suggesting a shared mechanism.

medRxiv
Northwestern University (US), University of North Carolina at Chapel Hill (US), Brigham and Women's Hospital (US), Albert Einstein College of Medicine (US), Beth Israel Deaconess Medical Center (US), Harvard University (US), University of Miami (US), University of Illinois Urbana-Champaign (US), University of California, Los Angeles (US), Wayne State University (US), University of California San Diego (US), University of Illinois Chicago (US), Office of Minority Health (US), Children's Hospital at Montefiore (US), National Institute on Aging (US), Columbia University (US), The University of Texas Health Science Center at Houston (US)
Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, Institut National Du Cancer, National Institutes of Health, University of Illinois at Urbana-Champaign, Gillings School of Public Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Minority Health and Health Disparities
Good health and well-being
Openalex Percentile: Top 68%
Sleep and related disorders
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