Genetic risk factors modulate the association between physical activity and colorectal cancer

In summary, we identified two genetic variants that modified the association between physical activity and CRC risk. One of them, related to GREM1 and SCG5, suggests that the bone morphogenetic protein (BMP)-related, inflammatory, and/or insulin signaling pathways may be involved in the protective association between physical activity and colorectal carcinogenesis.

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Publication Details

Journal
BMC Medicine
Published
2026-02-05
DOI
https://doi.org/10.1186/s12916-026-04675-5
Primary Topic
Genetics and Physical Performance
Type
article
Field-Weighted Citation Impact
0.00

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article

Genetic risk factors modulate the association between physical activity and colorectal cancer

Schoen Re, Andre E. Kim, Anna A. Kiseleva, Konstantinos K. Tsilidis et al.
BMC Medicine
Genetics and Physical Performance
article

Genetic risk factors modulate the association between physical activity and colorectal cancer

Schoen Re, Andre E. Kim, Anna A. Kiseleva, Konstantinos K. Tsilidis, Bens Budiarto Pardamean, E. WHITE, D Li, Nikos Papadimitriou, Bethany Van Guelpen, Victor Moreno, Christina C. Newton, Yu Tian, V. Martín, Claire Elizabeth Thomas, Carolyn M. Hutter, Michael O. Woods, Eric S. Kawaguchi, Juan Pablo Lewinger, Andrew J. Pellatt, C. Ulrich, Brigid Mary Lynch, Marianna C. Stern, Rama Pai, N. Murphy, Emmanouil Bouras, Anna Shcherbina, Rennert Gad, Mila Pinchev, Loic Le Marchand, Franzel J. B. van Duijnhoven, Alicja Wolk, David V. Conti, Sonja I. Berndt, A. Kundaje, Yubo Fu, Caroline Y. Um, Niki Dimou, Conghui Qu, Jennifer Ose, Anita R. Peoples, H B Brenner, Shuji Ogino, Jun Wang, Volker Arndt, D. Timothy Bishop, Daniel D. Buchanan, Sheetal Hardikar, Elizabeth A. Platz, Ferran Moratalla-Navarro, Yi Lin, Andrew T. Chan, John D. Potter, Anna H. Wu, Temitope O. Keku, Li Hsu, Michael O. Woods, Stephen B. Gruber, Julie R. Palmer, Douglas AC. Corley, Lori C. Sakoda, Jenny Chang-Claude, Mireia Obón-Santacana, W. James Gauderman, Yu-Ru Su, Michael Hoffmeister, John Morrison, Li Li, David A. Drew, Edward A. Ruiz-Narvaez
article en

Abstract

In summary, we identified two genetic variants that modified the association between physical activity and CRC risk. One of them, related to GREM1 and SCG5, suggests that the bone morphogenetic protein (BMP)-related, inflammatory, and/or insulin signaling pathways may be involved in the protective association between physical activity and colorectal carcinogenesis.

BMC MedicineVol. 24(1)
Broad Institute (US), Boston University (US), University of North Carolina at Chapel Hill (US), University of Southern California (US), University of Hawaiʻi at Mānoa (US), Brigham and Women's Hospital (US), American Cancer Society (US), National Institutes of Health (US), Albert Einstein College of Medicine (US), City Of Hope National Medical Center (US), Memorial University of Newfoundland (CA), University of Leeds (GB), The Royal Melbourne Hospital (AU), University of Hawaii System (US), Kaiser Permanente (US), The University of Texas MD Anderson Cancer Center (US), Harvard University (US), Johns Hopkins University (US), Kaiser Permanente Washington Health Research Institute (US), Universität Hamburg (DE), The University of Melbourne (AU), Binus University (ID), Technion – Israel Institute of Technology (IL), German Cancer Research Center (DE), Capital Medical University (CN), University of Veterinary Medicine Hannover, Foundation (DE), University of Ioannina (GR), Cancer Council Victoria (AU), University of Washington (US), University of Utah (US), Heidelberg University (DE), University of Michigan (US), Huntsman Cancer Institute (US), Bellvitge University Hospital (ES), Office of Public Health Genomics (US), Karolinska Institutet (SE), Institut d'Investigació Biomédica de Bellvitge (ES), Massachusetts General Hospital (US), Fred Hutch Cancer Center (US), Cancer Center of Hawaii (US), Victorian Comprehensive Cancer Centre (AU), Institut Català d'Oncologia (ES), University Medical Center Hamburg-Eppendorf (DE), National Center for Tumor Diseases (DE), Carmel Medical Center (IL), Utah Department of Health (US), Kaiser Permanente San Francisco Medical Center (US), Mayo Clinic in Arizona (US), University Cancer Center Hamburg (DE), University of Pittsburgh Medical Center (US), National Cancer Institute (US), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES), Centre international de recherche sur le cancer (FR), University of Hawaii Cancer Center, Imperial College London (GB), Massey University (NZ), University of Virginia (US), Clalit Health Services (IL), Universitat de Barcelona (ES), Universidad de León (ES), Umeå University (SE), Wageningen University & Research (NL), Stanford University (US)
U.S. Department of Health and Human Services, Fred Hutchinson Cancer Research Center, Johns Hopkins University, Bundesministerium für Bildung und Forschung, National Institutes of Health, Centers for Disease Control and Prevention, Canadian Institutes of Health Research, Ontario Ministry of Research and Innovation, National Cancer Institute, Office of Research Infrastructure Programs, National Institutes of Health
Good health and well-being
Openalex Percentile: Top 63%
Genetics and Physical Performance
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