Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion
We found a strong association of the SASP and NF-κB related inflammation with frailty in PWH. Osteoprotegerin can inhibit osteoclast formation and prevent bone resorption. Low proportion of naïve CD4 T cells and increased TIGIT and PD-1 expression were associated with both osteroprotegerin levels and frailty, suggesting a link between inflammation, T cell activation, bone health, and frailty in PWH.
Authors
- Carey L. Shive (ORCID: https://orcid.org/0000-0002-6908-1246)
- Wendy Fitzgerald (ORCID: https://orcid.org/0000-0001-5752-8250)
- Michael L. Freeman (ORCID: https://orcid.org/0000-0002-7690-5258)
- Leonid Margolis
- Brigid Wilson
- Katherine Tassiopoulos (ORCID: https://orcid.org/0000-0003-4773-2535)
- Kunling Wu
- Katelyn A O’Hare (ORCID: https://orcid.org/0009-0007-3380-2527)
- Brian M Clagett
- Kristine M Erlandson
- Vikhyath Jonnalagadda
Institutions
- Harvard University (US)
- Ilia State University (GE)
- Cancer Research And Biostatistics (US)
- VA Northeast Ohio Healthcare System (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University of Colorado Anschutz Medical Campus (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1093/infdis/jiag046
- Citations
- 1
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 38.36