Targeting spinal cord perfusion pressure in acute spinal cord injury through cerebrospinal fluid drainage: A prospective multi-center clinical trial
Ultimately, our protocol resulted in little CSF being drained, limited modification of ITP and SCPP, and no effect on neurological recovery. The relationship between CSF drainage volume and change in ITP was surprisingly unclear. This study revealed that draining CSF is more complex in traumatic SCI than in TAAA surgery patients. Future efforts to reduce ITP through CSF drainage likely need to address the occlusion of the subarachnoid space at the injury site through aggressive surgical decompression techniques.
Authors
- Angela Tsang (ORCID: https://orcid.org/0000-0002-6713-6354)
- J. Adam Wilson (ORCID: https://orcid.org/0000-0002-6989-2188)
- Anthony M. DiGiorgio (ORCID: https://orcid.org/0000-0002-5710-691X)
- Christian B. Ricks
- J. M. Mac-Thiong
- Lise Bélanger (ORCID: https://orcid.org/0000-0002-4261-1059)
- Cameron M. Gee (ORCID: https://orcid.org/0000-0003-0333-1836)
- B K Kwon
- Scott Paquette
- John Street
- Sean Christie
- Nicolas Dea
- Leanna Ritchie
- David Okonkwo
- Miko McKenzie
- Charlotte Dandurand
- Raphaele Charest-Morin
Institutions
- University of Nebraska–Lincoln (US)
- Dalhousie University (CA)
- University of British Columbia (CA)
- Medical University of South Carolina (US)
- University of New Mexico (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- Vancouver General Hospital (CA)
- International Collaboration On Repair Discoveries (CA)
- Neurological Surgery (US)
- Université de Montréal (CA)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1371/journal.pmed.1004925
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00