Comprehensive analysis of mitophagy-related genes reveals prognostic signatures in breast cancer: based on immune landscapes and treatment target predict
This study elucidated the prognostic value, immune microenvironment characteristics, and molecular mechanisms of mitophagy in BC, and identified nine mitophagy-related biomarkers. Among them, PBK and NEK2 were experimentally confirmed to promote tumor cell proliferation, providing novel insights for early diagnosis and therapeutic strategies in breast cancer.
Authors
- Fei Zou (ORCID: https://orcid.org/0000-0002-6305-1070)
- Yiheng Du
- Yilan Tan
- Wanying Zhang
- Hejia Zhao
- Zheng Kuang
- Yujie Ma
- Yanjun Chen
Institutions
- Southern Medical University (CN)
- Nagoya University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1740830
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00