EXO-VNN2 derived from 3D-cultured DPSCs enhances the inflammatory response of PDLSCs and suppresses bone regeneration in periodontitis
This study reveals for the first time that DPSC-EXO-VNN2 participates in the progression of periodontitis by regulating the inflammatory response and osteogenic differentiation ability of PDLSCs. Future research may further explore the potential application of targeting VNN2 in treating periodontitis.
Authors
- Qin Zhou (ORCID: https://orcid.org/0000-0001-7249-8782)
- Zhenzhen Wang (ORCID: https://orcid.org/0000-0002-4456-8752)
- Xiaoxu Liu
- J. Xu
- Mengting Li
Institutions
- Xuzhou Medical College (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1186/s13287-026-04922-9
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00