Pinpointing protein as the problem

A genetic repeat expansion linked to two neurodegenerative disorders harms neurons through toxic proteins, not RNA.

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Journal
Science
Published
2026-02-05
DOI
https://doi.org/10.1126/science.aee6924
Primary Topic
Genetic Neurodegenerative Diseases
Type
article
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article

Pinpointing protein as the problem

Frederick J. Arnold, Albert R. La Spada
Science
Genetic Neurodegenerative Diseases
article

Pinpointing protein as the problem

Frederick J. Arnold, Albert R. La Spada
article en

Abstract

A genetic repeat expansion linked to two neurodegenerative disorders harms neurons through toxic proteins, not RNA.

ScienceVol. 391(6785)
University of California, Irvine (US), Washington University in St. Louis (US)
Zero hunger
Openalex Percentile: Top 67%
Genetic Neurodegenerative Diseases
DOISourceOpenAlex
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Pinpointing protein as the problem — Frederick J. Arnold, Albert R. La Spada · Science (2026) | TGRS Research Map | TGRS