Analysis of the association between SLCO1B1 gene polymorphisms and coronary heart disease risk in southern Han Chinese population and statin responses in the elderly

The <i>SLCO1B</i>1 c.521C allele represents an independent genetic marker for CHD susceptibility in the southern Han Chinese population. In geriatric populations, standard-dose statin therapy maintains lipid-lowering efficacy and safety, unaffected by the <i>SLCO1B1</i> c.521T>C polymorphism. Our findings provide a genetic screening tool for the primary prevention of cardiovascular diseases and offer support for the efficacy and safety of statin-based lipid-lowering therapy in adults aged >75 years.