Healthy young human plasma-derived exosomes enhance neural stem cell therapy by suppressing pyroptosis via TXNIP/NLRP3 after intracerebral hemorrhage
Our study elucidates a previously unidentified mechanism whereby Y-exo improve neurological outcomes by alleviating the peri-hematoma inflammatory microenvironment, suppressing pyroptosis in transplanted stem cells, and altering their differentiation fate. This study highlights the potential of synergistic strategy to optimize NSCs-based therapy for stroke by combining youth-derived factors, offering new insights into regenerative therapeutics for neurological disorders.
Authors
- Ziqiang Chen (ORCID: https://orcid.org/0000-0002-6726-5084)
- Fuan Zhang
- Q. Zhang
- Huanhuan Li (ORCID: https://orcid.org/0000-0001-5260-6993)
- Jiao Chen (ORCID: https://orcid.org/0000-0003-0830-6242)
- Pangbo Wang
- Fengchun Zhao
- Shengtao Yao
- Rong Hu
- Haomiao Wang
- Ran Luo
- Ning Ding
Institutions
- Army Medical University (CN)
- Zunyi Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Southwest Hospital (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s12951-026-04099-6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Army Medical University