Electroacupuncture protects gastric Cajal cells by reducing macrophage pyroptosis in diabetic gastroparesis
HEA ameliorates gastric dysmotility in DGP by suppressing the cGAS-STING pathway, attenuating M2 macrophage pyroptosis and inflammatory responses, and preserving ICC networks. These findings identify a novel EA/cGAS-STING/pyroptosis axis and highlight its therapeutic potential as a mechanistic target for optimizing DGP treatment strategies.
Authors
- Mingwei Fan
- Cheng-Xia Liu
- Shu-Hui Zhang
- Zi-Jian Zhao
- Yan Mi Na Chen
- Jin-Lan Tian
- Xin-Ru Liu
Institutions
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2026-02-06
- DOI
- https://doi.org/10.4239/wjd.v17.i2.114252
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00