HIV Membrane-Proximal External Region Scaffolded Immunogen as Killed Whole-Cell Genome-Reduced Vaccines
These results demonstrate that a KWC/GRB-based scaffold-MPER (3AGJ) vaccine can elicit HIV-1 neutralizing antibodies in a subset of animals. Although further optimization will be required to improve the consistency and magnitude of neutralizing responses, the findings provide an initial validation of the concept. There are many strategies that can be used to enhance and extend immune responses induced by KWC/GRB vaccines that can be employed to yield improved anti-HIV-1 immune responses.
Authors
- Steven L. Zeichner (ORCID: https://orcid.org/0000-0002-8922-9260)
- Yufeng Song (ORCID: https://orcid.org/0009-0001-6788-1717)
- Frances Mehl (ORCID: https://orcid.org/0009-0005-9929-3185)
- Shubham Mathur
- Juan Sebastian Quintero-Barbosa
- Lauren Livingston
- Xiaoying Shen
- David C. Montefiori
- Peter D. Kwong
Institutions
- National Institutes of Health (US)
- Aaron Diamond AIDS Research Center (US)
- Duke University (US)
- National Institute of Allergy and Infectious Diseases (US)
- University of Virginia (US)
- Columbia University (US)
Publication Details
- Journal
- Viruses
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3390/v18020209
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00