Synthesis and preclinical development of a novel 68Ga/89Zr-Labelled ανβ6-integrin targeting trimer
FSC(PEG4-αvβ6)₃ represents the first-generation tracer targeting the αvβ6 integrin based on the multifunctional chelator Fusarinine C, thereby expanding the repertoire of radionuclides applicable from Gallium-68 to Zirconium-89. Following further optimization, this novel class of compounds holds significant promise for enabling clinical translation and advancing the development of next-generation αvβ6-directed imaging agents.
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Translational Research in Oncology (FR)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s41181-025-00423-x
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00