Cardiorespiratory phase synchronization maturational trajectory: biomarker of autonomic nervous system development in preterm infants
Cardiorespiratory phase synchronization (CRPS) trajectories, a marker of autonomic nervous system functio is provided for 175 extremely preterm infants across post-menstrual age (PMA) and chronological age (CA). CRPS initially declines but subsequently increases with advancing PMA and CA, irrespective of discharge status and respiratory and neurological outcomes at 40 weeks PMA. At all CAs after the initial decrease, CRPS was higher for infants born at 27-28 weeks compared to those born earlier.
Authors
- Narayanan Krishnamurthi (ORCID: https://orcid.org/0000-0002-0174-8737)
- Michael S. Carroll (ORCID: https://orcid.org/0000-0002-0526-7543)
- Casey M. Rand (ORCID: https://orcid.org/0000-0003-1077-8978)
- Aaron Hamvas (ORCID: https://orcid.org/0000-0002-5749-7797)
- Susan M. Slattery (ORCID: https://orcid.org/0000-0003-1894-0044)
- Casey M Rand
- Lynn Boswell (ORCID: https://orcid.org/0000-0002-0280-7065)
- Ryne Estabrook (ORCID: https://orcid.org/0000-0002-0053-2010)
- Debra E. Weese-Mayer
- Raye-Ann deRegnier
Institutions
- Northwestern University (US)
- Lurie Children's Hospital (US)
- University of Illinois Chicago (US)
- Lurie Children's Hospital (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1038/s41390-026-04783-1
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Northwestern University
- National Institutes of Health