A red blood cell–based antigen delivery system to facilitate T cell epitope presentation to promote peripheral tolerance to ADAMTS13 in immune-mediated thrombotic thrombocytopenic purpura
Based on our results, we propose RBC-mediated delivery of ADAMTS13-derived peptides as a potential strategy for promoting tolerance in patients with iTTP.
Authors
- Stijn A. Groten (ORCID: https://orcid.org/0000-0002-9438-9939)
- Erik Mul (ORCID: https://orcid.org/0000-0002-8234-9972)
- Pieter Langerhorst (ORCID: https://orcid.org/0000-0002-4718-1764)
- Mariarosaria Miranda
- Margot Dierickx
- Carmen van der Zwaan
Institutions
- Amsterdam UMC Location University of Amsterdam (NL)
- Sanquin (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.rpth.2026.103387
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Research Executive Agency
- H2020 Marie Skłodowska-Curie Actions