Reduced retinal microvascular density in patients with mixed connective tissue disease: an exploratory pilot study on the interplay between aging, renal function, and complement system
Patients with MCTD present subclinical retinal microvascular abnormalities detectable by OCT-A. Our hypothesis-generating study suggests that retinal vascular changes may be linked to disease duration, renal function, and complement levels. OCT-A may be a useful tool for assessing MCTD.
Authors
- Carolina Nesi
- P. Triggianese
- B. Kroegler
- Anna Paola Mitterhofer (ORCID: https://orcid.org/0000-0002-0132-386X)
- M. Cesareo
- Raffaele Mancino (ORCID: https://orcid.org/0000-0001-9968-9714)
- Alessio Martucci (ORCID: https://orcid.org/0000-0002-3725-8211)
- Arianna D’Antonio (ORCID: https://orcid.org/0000-0003-1872-5299)
- David Della-Morte
- Eugenio Capparelli
- Carlo Nucci
- Marco Lombardo
- Alberto Bergamini
Institutions
- University of Rome Tor Vergata (IT)
- Policlinico Tor Vergata (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1724780
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00