Integrated analysis of global regulators and efflux genes associated with antimicrobial resistance reversal in multidrug resistant Klebsiella pneumoniae
Our integrated findings indicate that higher marA/soxS expression is associated with increased gene expression of the AcrAB-TolC efflux pump and fluoroquinolone resistance in clinical MDR isolates, while PAβN-mediated efflux inhibition is associated with partial susceptibility restoration. Together, these results highlight global regulators and efflux pumps as actionable therapeutic targets for resistance reversal.
Authors
- Ali Jalil Obaid (ORCID: https://orcid.org/0000-0001-6385-8125)
- Maryam Sabah Naser
- Ali Jabbar Abd Al-Hussain Alkawaz
Institutions
- University of Babylon (IQ)
- Green University of Bangladesh (BD)
- Ministry of Higher Education and Scientific Research (IQ)
- University of Kerbala (IQ)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1038/s41598-026-37272-w
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Kerbala