Photoirradiation-Promoted ipso-Azidation of 1-Aryltriazenes
Ultraviolet (UV) irradiation (λ_<max> = 370 nm) of a methanol solution of 1-aryltriazenes and azidotrimethylsilane promotes ipso-azidation. Optimization of the reaction conditions and a mechanistic study revealed that the hydrazoic acid generated in situ enabled efficient transformation. The high functional group tolerance of this reaction allowed for the transformation of a broad range of 1-aryltriazenes, including those introduced on a protein, to the corresponding aryl azides.
Authors
- Isao Kii (ORCID: https://orcid.org/0000-0002-6153-6250)
- Takamitsu Hosoya (ORCID: https://orcid.org/0000-0002-7270-351X)
- Takashi Niwa (ORCID: https://orcid.org/0000-0002-6209-5362)
- Satoshi Fukuda
- Yamato Ezo
Publication Details
- Journal
- QIR (Kyushu University Institutional Repository) (Kyushu University)
- Published
- 2025-09-29
- Primary Topic
- Chemical Reactions and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00