Human Monoclonal Antibody against hIL18 Receptor Accessory Protein Chain Promotes Anti-Tumor Activity in Triple-Negative Breast Cancer.
Our findings highlight the therapeutic potential of targeting IL-18RAcP in TNBC through modulation of IL-18/IL-18R-mediated signaling pathways. The development of scFvAPC10 offers a promising approach for novel antibody-based therapies in the treatment of TNBC.
Authors
- Wenxi Yu (ORCID: https://orcid.org/0000-0002-0391-4196)
- Yonggang Wang
- Feng Lin
- Guowei Qian
- Lina Tang
- Fang Hu
Institutions
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2026-02-03
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00