Atypical dermatomyositis with positive anti-nuclear matrix protein 2 antibodies complicated by rhabdomyolysis syndrome: a case report and literature review

Adult anti-NXP-2 antibody-positive dermatomyositis complicated by rhabdomyolysis has been documented only sporadically; its co-occurrence is estimated at <1%, placing it in the ultra-rare category. The precise pathogenic role of this antibody in systemic autoimmunity remains undefined, and systematic evidence linking it to rhabdomyolysis is lacking. Future multi-omic profiling and functional studies are required to determine whether the two disorders share a common mechanistic pathway.