Perinatal HIV exposure is associated with long-term alterations in immune marker levels in children

Perinatal HIV exposure induces persistent immune alterations, even in uninfected children, including elevated cytokines, immune-checkpoints, thrombosis and vascular inflammation markers. These findings suggest that, even without acquiring HIV, exposed children exhibit immunological imprints that may contribute to increased risk of adverse health outcomes.

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Publication Details

Journal
Journal of Infection and Public Health
Published
2026-02-04
DOI
https://doi.org/10.1016/j.jiph.2026.103168
Citations
1
Primary Topic
HIV Research and Treatment
Type
article
Field-Weighted Citation Impact
27.20
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Perinatal HIV exposure is associated with long-term alterations in immune marker levels in children

Noris Pavía-Ruz, Judit Ventosa-Cubillo, R. A. Muñoz-Hernández, Concepción Rodríguez-Jiménez et al.
1 citations
Journal of Infection and Public Health
HIV Research and Treatment
27.20
article

Perinatal HIV exposure is associated with long-term alterations in immune marker levels in children

Noris Pavía-Ruz, Judit Ventosa-Cubillo, R. A. Muñoz-Hernández, Concepción Rodríguez-Jiménez, Dulce Morales-Pérez, José Avendaño-Ortiz, María Luisa Navarro, África Holguín
article en
1 citations

Abstract

Perinatal HIV exposure induces persistent immune alterations, even in uninfected children, including elevated cytokines, immune-checkpoints, thrombosis and vascular inflammation markers. These findings suggest that, even without acquiring HIV, exposed children exhibit immunological imprints that may contribute to increased risk of adverse health outcomes.

Journal of Infection and Public HealthVol. 19(4)
Hospital General Universitario Gregorio Marañón (ES), Hospital Infantil de México Federico Gómez (MX), Instituto Ramón y Cajal de Investigación Sanitaria (ES), Universidad Nacional Autónoma de México (MX)
Good health and well-being
Openalex Percentile: Top 1%
HIV Research and Treatment
27.20
DOIOpen Access PDFOpenAlex
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