Association between selective serotonin reuptake inhibitors and 28-day in-hospital mortality in critically ill patients with depression: A cohort study stratified by exposure timing

In ICU patients with comorbid depression, overall SSRI exposure was not clearly associated with 28-day mortality after time-aligned analyses. A lower mortality signal was observed for post-ICU initiation, whereas pre-ICU maintenance use showed no survival advantage. These findings are hypothesis-generating and warrant prospective confirmation.