Impact of ischemia duration on MRI-derived perfusion parameters in a mouse kidney transplant model
The duration of ischemia critically affects endothelial integrity and perfusion characteristics in a mouse kidney transplant model. Prolonged 16-h ischemia leads to increased vascular permeability, indicating more severe endothelial and microcirculatory injury in transplanted kidneys. DCE-MRI enables sensitive detection of subtle ischemia-related microvascular alterations, supporting its value for noninvasive graft assessment.
Authors
- Severin Jacobi (ORCID: https://orcid.org/0000-0003-1804-5090)
- C. Walz
- C Cyran
- Robert Erdelkamp
- Felix L. Herr
- Ulrich Wirth (ORCID: https://orcid.org/0000-0003-2366-8524)
- Joachim Andrassy (ORCID: https://orcid.org/0000-0001-8303-3913)
- Jens Ricke
- Sandra Kloiber-Langhorst
- Olaf Dietrich
- Ming Ming Li
Institutions
- LMU Klinikum (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1186/s41747-025-00675-x
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft