How Much Difference Does Depression Make to the Outcome of Neuropsychological Assessments of Patients With Epilepsy?

In PWE, depression has a severe primary impact on quality of life. Its direct effect on cognition, however, is minor. When a cognitive effect is present, it suggests hypofrontality impacting attention, executive functions, and motor skills, predominantly in the most severely depressed patients (BDI > 29). The influence of depression on global cognitive impairment is mediated through this executive dysfunction.