Causal associations between abdominal obesity, dietary patterns, and intervertebral disc degeneration: a bidirectional two-sample Mendelian randomization study with clinical validation
Our findings support a causal role for abdominal obesity-specifically WC and ASAT-in IVDD development, independent of general adiposity. Furthermore, specific dietary patterns may significantly influence IVDD risk. These results highlight the potential of targeted nutritional and body composition interventions in the prevention and management of IVDD, currently supported by both genetic and clinical evidence.
Authors
- Y J Wang
- Zhonghao Dai
- Xu Wang (ORCID: https://orcid.org/0000-0001-5354-291X)
- Bing Xu (ORCID: https://orcid.org/0009-0006-4197-9050)
- Zezhong Liu
- Jiaoyi Pan
- BaiTong Zhao
- ZiTong Zhang
- GuoYu Ling
- XingYong Mao
Institutions
- Zhejiang Chinese Medical University (CN)
- Wenzhou Hospital of Traditional Chinese Medicine (CN)
- The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fmed.2026.1763791
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Zhejiang Traditional Chinese Medicine Administration