Antifungal secondary metabolites from a mangrove-derived fungus <i>Daldinia eschscholtzii</i> TGM23

One new compound daldiniaone A (<b>1</b>), along with six known compounds 1-(2,6-dihydroxyphenyl)ethan-1-one (<b>2</b>), 1-(2,6-dihydroxyphenyl)butan-1-one (<b>3</b>), penicilliode B (<b>4</b>), (4-hydroxy-3-methoxyphenyl)acetic acid (<b>5</b>), 2-(4-methoxyphenyl)acetic acid (<b>6</b>), and 2-(2-hydroxyethyl)phenol (<b>7</b>), were obtained from the EtOAc extract of the mangrove-derived fungus <i>Daldinia eschscholtzi</i>i TGM23. Their structures were characterized by comprehensive spectral analysis, including nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HR-ESI-MS), and electronic circular dichroism (ECD) spectra. All the isolated compounds were tested for their inhibitory activity against three plant pathogenic fungi. Compound <b>6</b> showed inhibitory activity against <i>Phytophthora capsici</i>, with the EC₅₀ value of 106.5 μg/ml. Compound <b>7</b> exhibited inhibitory activity against <i>Botrytis cinerea</i> with the EC₅₀ value of 86.8 μg/ml.