Astrocytic CCL5 orchestrates CCR5-positive neuronal necroptosis in subarachnoid hemorrhage
Our study unveils that astrocytic CCL5 orchestrates CCR5-dependent neuronal necroptosis via NF-κB/p-RIPK3/p-MLKL signaling, thereby driving EBI after SAH. These findings establish the CCL5/CCR5 axis as a potential therapeutic target for mitigating brain injury and cognitive dysfunction in SAH patients.
Authors
- Yuhe Jiang
- Si-jun Li
- Jun-Xin Zhao
- Meng-Yu Shi
- Z Ye
- Qing-Song Lin
- De-Zhi Kang
- Si-Qi Xue
- Ying Wang
- Wan-Lan Lin
- Ping Chen
- Wei-Wei Sun
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1186/s12974-026-03714-5
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00