METTL3 promotes pancreatic cancer immune escape by m6A modification of lncRNA AFAP1-AS1 to enhance EGR2 stability
METTL3 enhances AFAP1-AS1 stability via m6A modification recognized by YTHDF2 and IGF2BP1, which subsequently increases EGR2 expression by improving its mRNA stability. EGR2 directly activates transcription of immune checkpoint and epithelial-mesenchymal transition (EMT)-related genes. This METTL3/AFAP1-AS1/EGR2 signaling axis drives PC malignancy and immune resistance, offering potential therapeutic targets for PC treatment.
Authors
- Daojun Zhu
- Rongxi Shen (ORCID: https://orcid.org/0000-0002-5723-1876)
- Min Li
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1186/s40001-026-03963-3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00