Analyzing the genetic profile of autistic children and adolescents with minimal verbal abilities
This is the first study analyzing the genotype-phenotype correlation in MV autistic individuals. In this sample, the prevalence of genetic syndromes was found to be twice as high as in the general autistic population (22.6% <i>versus</i> 10%). Regarding the autistic characteristics' severity which appear to be higher in individuals without genetic causative alteration and the absence of significant differences in cognitive, functional and behavioural characteristics, we hypothesised that, in the MV autistic population without genetic causative alteration, there are specific and unknown characteristics of the MV profile which have a greater impact than the individual genetic condition reported.
Authors
- M. Cristina Digilio (ORCID: https://orcid.org/0000-0002-9168-3606)
- Cristina Roberti
- Lorenzo Sinibaldi (ORCID: https://orcid.org/0000-0002-1371-936X)
- Silvia Di Tommaso (ORCID: https://orcid.org/0000-0002-8407-9136)
- Fabiana Cortellessa
- Marina Macchiaiolo (ORCID: https://orcid.org/0000-0001-7409-8299)
- Ilaria Venezia (ORCID: https://orcid.org/0000-0002-1198-9411)
- Federico Casciani
- Viola Alesi
- Gemma D'Elia
- Maria Grazia Logrieco
- Laura Casula
- Antonio Novelli
- Giovanni Valeri
- Silvia Guerrera
- Stefano Vicari
Institutions
- University of Foggia (IT)
- AOL (United States) (US)
- University of the Humanities (MN)
- Bambino Gesù Children's Hospital (IT)
- Catholic University of America (US)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fgene.2026.1647481
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute