Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection
Activation of LepR in the brain protects the heart after ischemia-reperfusion injury via sympathetic-mediated BAT-derived EVs enriched with miR-29c-3p.
Authors
- John E. Hall (ORCID: https://orcid.org/0000-0001-9867-5855)
- John Carl Young
- X. Li
- Alan J. Mouton (ORCID: https://orcid.org/0000-0001-5973-3071)
- Cortland H. Johns
- Robert W. Spitz (ORCID: https://orcid.org/0009-0007-4270-6932)
- Xuemei Dai
- Emily C. Ladnier
- Luísa Rodrigues Romeiro
- Madison Hamby
- Alexandre A. da Silva
- Craig J. Goergen
- Ana C.M. Omoto
- Sumaya C. Zenum
- Jussara M. do Carmo
- Ivan Vechetti
- Alyssa M. Richards
- Odecio E.S. Tosta
- Zhen Wang
Institutions
- University of Nebraska–Lincoln (US)
- Purdue University West Lafayette (US)
- University of Mississippi Medical Center (US)
- Centro Universitário Barão de Mauá (BR)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1161/circresaha.125.326878
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00