ANTI-INFLAMMATORY EFFECT OF BILBERRY (VACCINIUM MYRTILLUS L.) PREPARATION: A SYSTEMATIC REVIEW

<p class="cvGsUA direction-ltr align-justify para-style-body" style="text-align: justify;"><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">Naturally-derived anti-inflammatories, such as bilberry (</span><em><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">Vaccinium myrtillus</span></em><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">), are particularly interesting due to their health benefits. Bilberries are a rich source of primary metabolites such as sugars and organic acids, which give the fruit its taste. They also contain anthocyanins, the most abundant group of secondary metabolites, possessing various biological properties, including anti-inflammatory effects. This paper aimed to collect the current knowledge on the bioactive compounds of <em>V. myrtillus </em>berries, and to summarize clinical studies of the anti-inflammatory effects of different bilberry preparations. </span><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">Literature review was conducted utilizing the databases PubMed, Scopus, Web of Science, Science Direct, NCBI, Google Scholar and ClinicalTrials.gov. </span><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none"><em>V. myrtillus </em>was found to be a significant source of bioactive molecules since components of bilberry fruits, such as polyphenols, anthocyanins, and flavonoids, are well known for their ability to modify cellular pathways implicated in the pathophysiology of a number of diseases. A short review of the clinical study data related to the bilberry application highlighted its health-promoting effects, specifically the anti-inflammatory effect. </span><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">The bilberry fruit is a rich source of phenolic compounds with high biological potential. These compounds can be used commercially in pharmacy, cosmetics, and natural products markets. However, due to the wide variety of constituents in the fruit, their potential interactions, and the complexity of their metabolism, further in-depth studies are needed to better define and characterize the contribution of each active component and possible synergies between different compounds. Numerous clinical studies have highlighted the anti-inflammatory properties of <em>V. myrtillus </em>fruits, which could help prevent various diseases.</span></p>