Innate and adaptive immune patterns in hospitalised COVID-19 patients: a framework for precision monitoring in viral and inflammatory syndromes
Specific immune profiles, particularly reductions in CD4+ and NK cells, are strong predictors of mortality or ICU admission in hospitalized COVID-19 patients. These findings suggest that rapid and clinically feasible tool may support precision monitoring and personalised management in viral and inflammatory syndromes beyond COVID-19. This study advocates for the integration of immune profiling into the framework of precision medicine.
Authors
- Salvatore Scibetta (ORCID: https://orcid.org/0009-0003-3236-3340)
- Raffaella Mallaci Bocchio
- Francesco Gervasi (ORCID: https://orcid.org/0000-0002-9052-7206)
- Antonella Montalbano
- Luigi Calvo (ORCID: https://orcid.org/0009-0009-2702-5551)
- Giuseppe Natoli
- Salvatore Corrao
- Christiano Argano
- Internal Medicine IGR COVID-19 Investigators
Institutions
- National Academies of Sciences, Engineering, and Medicine (US)
- Department of Health (ES)
- Institute for Biomedical Research and Innovation (IT)
- University of Palermo (AR)
- Azienda di Rilievo Nazionale ed Alta Specializzazione (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1683748
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00