Association of various insulin resistance surrogate indices with aging acceleration and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: insights from CHARLS 2011–2020 data
Multiple IR surrogate indices independently predict cardiovascular disease in CKM stages 0-3, with biological aging acceleration mediating this association. Integrating these measures into risk stratification could enable early identification and targeted intervention for high-risk individuals.
Authors
- Feng Cheng
- Ping-wei Li
- Zhiming Zeng
- Jiang-Bo Li
- Ying Li
- Qin Liu
- Pian Zhong
- Shu-Shu Han
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Anshan Hospital (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1186/s12933-026-03084-5
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00