Association of Changes in Portal Insulin with Immunometabolism During and After Hepatitis C Virus Infection
Insulin resistance is a common extrahepatic manifestation of hepatitis C virus (HCV) infection (HCVi), but its mechanism is poorly understood. While systemic insulin resistance is documented, portal insulin dynamics, a key regulator of hepatic metabolism, remain unexplored. This study aimed to investigate the relationship between insulin, the gut-liver axis, and immunometabolic changes in patients with HCV.
Authors
- Moumita Chakraborty (ORCID: https://orcid.org/0000-0001-7509-1777)
- James A. Haddad (ORCID: https://orcid.org/0000-0003-4525-4007)
- Rebecca Brown (ORCID: https://orcid.org/0000-0001-5110-2750)
- Shakuntala Rampertaap
- Lisa Scheuing
- Rownock Afruza (ORCID: https://orcid.org/0000-0002-0963-3248)
- Ohad Etzion (ORCID: https://orcid.org/0000-0001-9254-2154)
- Rabab Ali (ORCID: https://orcid.org/0000-0001-6222-338X)
- Regina Umarova
- Elizabeth C. Townsend (ORCID: https://orcid.org/0000-0003-3102-8033)
- Matthew G Menkart (ORCID: https://orcid.org/0009-0002-0618-5934)
- Jenna Oringher
- Kareen L. Akiva (ORCID: https://orcid.org/0000-0002-4593-9439)
- Theo Heller
- Elliot B. Levy
- David E. Kleiner
- Gabriella M. Quinn
- Christopher Koh
- Anjali Rai
- Grace Zhang
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.14218/jcth.2025.00498
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- NIH Clinical Center