The integration of plasma non-target metabolomics and lipidomics analysis for the discovery of global developmental delay/intellectual disability biomarkers
This study identified putative biomarkers and metabolic pathways associated with GDD/ID, highlighting the potential of combined plasma metabolomics and lipidomics for early screening of GDD/ID and providing tentative insights into its pathophysiology. The biomarkers show strong diagnostic performance as screening tools, but future studies are needed to validate their prognostic value and clinical utility in multi-center cohorts.
Authors
- Miriam Kessi (ORCID: https://orcid.org/0000-0002-7932-9292)
- Shimeng Chen (ORCID: https://orcid.org/0000-0002-6745-6999)
- Baiyu Chen (ORCID: https://orcid.org/0000-0002-0567-7729)
- Juan Xiong
- Jing Peng
- Fei Yin
- Fang He
Institutions
- Central South University (CN)
- Mongolian National University (MN)
- Finnish Association of People with Physical Disabilities (FI)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fncel.2026.1688339
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Inner Mongolia Medical University