Endothelial LRRC8C Associates With LRRC8A and LRRC8B to Regulate Vascular Reactivity and Blood Pressure
LRRC8A/B/C form the endothelial LRRC8 heteromeric complex. LRRC8C is nonredundant in supporting endothelial AKT-endothelial NO synthase signaling, vascular relaxation, and resistance to hypertension.
Authors
- John D. Tranter (ORCID: https://orcid.org/0009-0006-6884-7154)
- Prakash Arullampalam (ORCID: https://orcid.org/0000-0001-5725-2290)
- Michelle Lin (ORCID: https://orcid.org/0000-0001-5367-1930)
- Carmen M. Halabi (ORCID: https://orcid.org/0000-0003-4889-8131)
- Rajan Sah (ORCID: https://orcid.org/0000-0003-1092-1244)
- Nathaniel John
- Tarek Mohamed Abd El-Aziz
- Qiujun Yu
- Joshua Maurer
- Yonghui Zhao
- Mehran Rahimi
Institutions
- Washington University in St. Louis (US)
- St. Louis VA Medical Center (US)
- Cardiovascular Research Center (BR)
- Minia University (EG)
Publication Details
- Journal
- Hypertension
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25889
- Citations
- 1
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 34.74