T cell and monocyte activation in concert with hematopoietic stem cell interactions shapes the post-allogeneic transplant immune landscape in poor graft function
Our results demonstrate a hyper-inflamed post-alloSCT environment involving both innate (monocytes) and adaptive (T cells) immune responses and their active interactions, more in PGF, highlighting that immune modulation may serve as an alternative or adjunctive therapeutic approach for PGF.
Authors
- Jessica Klass
- Xingmin Feng (ORCID: https://orcid.org/0000-0001-8018-2366)
- Huw Morgan (ORCID: https://orcid.org/0000-0001-9132-8738)
- Rachel Koldej (ORCID: https://orcid.org/0000-0002-1627-8934)
- Ashvind Prabahran (ORCID: https://orcid.org/0000-0003-3135-0401)
- Clarissa Wilson
- Nicholas Holzwart (ORCID: https://orcid.org/0009-0008-6707-0421)
- Mandy J. Ludford-Menting
- Mayani Rawicki
- Saanvi Indukuri
- Neal S. Young
- Piers Blombery
- David Ritchie
- Ray-Mun Koo
- Zhijie Wu
- Chin Wee Tan
- Shouguo Gao
- Lynette Chee
Institutions
- National Institutes of Health (US)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Australian Cancer Research Foundation (AU)
- Peter MacCallum Cancer Centre (AU)
- National Heart, Lung, and Blood Institute (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1750093
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00