TFE3 fusion proteins drive TFE3 rearranged renal cell carcinoma progression via PGC-1α-mediated fatty acid oxidation
<i>TFE3</i> fusion proteins enhance FAO and drive <i>TFE3</i> rRCC progression via the PGC-1α/PPARα/CPT1A axis. Targeting CPT1A could inhibit tumor cell proliferation, suggesting that this pathway may serve as a potential therapeutic target for <i>TFE3</i> rRCC.
Authors
- Yan Xu (ORCID: https://orcid.org/0000-0002-3319-4695)
- ZhengGen Deng
- Xiulin Dong
- Guijuan CHEN
- Wenliang Ma
- Weidong Gan
- Dongmei Li
- Fan Feng
Institutions
- University of Electronic Science and Technology of China (CN)
- Yuhuangding Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1700983
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00