In vitro activity of eight antifungal drugs against clinical and hospital isolates of Candida parapsilosis complex; a multicenter study, 2023–2024
Despite the absence of detectable ERG11 or FKS1 mutations, reduced susceptibility to azoles and echinocandins was observed, primarily among clinical isolates. Environmental and healthcare worker isolates showed lower MIC values, suggesting minimal antifungal selection pressure outside patient care environments. These findings point to emerging antifungal resistance in C. parapsilosis clinical isolates in Iran and emphasize the importance of ongoing surveillance and molecular monitoring to inform therapeutic and infection control strategies. However more studies are required to correlate these findings with clinical outcomes.
Authors
- Azam Moslemi (ORCID: https://orcid.org/0000-0002-7324-7456)
- Iman Haghani (ORCID: https://orcid.org/0000-0001-9723-7618)
- Mohammad Taghi Hedayati (ORCID: https://orcid.org/0000-0001-6415-4648)
- Maryam Salimi (ORCID: https://orcid.org/0009-0002-8288-2555)
- حسین زرینفر
- Leila Faeli (ORCID: https://orcid.org/0000-0002-9479-0255)
- Seyed Reza Âghili (ORCID: https://orcid.org/0000-0001-9469-0054)
- Reza Valadan (ORCID: https://orcid.org/0000-0002-9074-6994)
- Hamid Badali (ORCID: https://orcid.org/0000-0002-6010-8414)
- T. Shokohi
- Mahdi Abastabar
- Sabah Mayahi
- Zoha Asgari
- Maryam Moazeni
Institutions
- Baqiyatallah University of Medical Sciences (IR)
- Mashhad University of Medical Sciences (IR)
- Islamic Azad University Sari Branch (IR)
- Texas Center for Infectious Disease (US)
- The University of Texas at San Antonio (US)
- Mazandaran University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1186/s12879-026-12598-y
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00