Nocturnal Hypoxia and Sleep-Disordered Breathing as Potential Early Biomarkers of Respiratory Progression in Mild ALS

In patients with mild ALS and normal daytime function, specific nocturnal PSG parameters (AHI, minimum SpO<sub>2</sub>) predicted the risk of dyspnea within 12 months. This longitudinal study provides novel evidence that PSG could identify early respiratory vulnerability in the incipient stage, earlier than conventional FVC-based monitoring, supporting its potential utility in refining early intervention strategies. Validation in larger cohorts is warranted.

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Publication Details

Journal
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Published
2026-02-04
DOI
https://doi.org/10.1017/cjn.2026.10557
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
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article

Nocturnal Hypoxia and Sleep-Disordered Breathing as Potential Early Biomarkers of Respiratory Progression in Mild ALS

Weijiang Ding, Xueming Li, Enwang Xu, Meiying Sun et al.
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Amyotrophic Lateral Sclerosis Research
article

Nocturnal Hypoxia and Sleep-Disordered Breathing as Potential Early Biomarkers of Respiratory Progression in Mild ALS

Weijiang Ding, Xueming Li, Enwang Xu, Meiying Sun, Yan Lu
article en

Abstract

In patients with mild ALS and normal daytime function, specific nocturnal PSG parameters (AHI, minimum SpO<sub>2</sub>) predicted the risk of dyspnea within 12 months. This longitudinal study provides novel evidence that PSG could identify early respiratory vulnerability in the incipient stage, earlier than conventional FVC-based monitoring, supporting its potential utility in refining early intervention strategies. Validation in larger cohorts is warranted.

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Shangrao Normal University (CN), Hebei Medical University (CN), Nanchang University (CN), First Affiliated Hospital of Jiangxi Medical College (CN), Second Affiliated Hospital of Nanchang University (CN), Xingtai People's Hospital (CN), Shangluo Central Hospital (CN), First Affiliated Hospital of Nanchang University (CN)
Zero hunger
Openalex Percentile: Top 68%
Amyotrophic Lateral Sclerosis Research
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Nocturnal Hypoxia and Sleep-Disordered Breathing as Potential Early Biomarkers of Respiratory Progression in Mild ALS — Weijiang Ding, Xueming Li, et al. · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (2026) | TGRS Research Map | TGRS