Survival Outcomes With or Without Risk-Reducing Mastectomy in <i>BRCA1</i> and <i>BRCA2</i> Pathogenic Variant Carriers

For women electing imaging surveillance over risk-reducing surgery, our results may offer reassurance that their breast cancer-specific survival and OS are unlikely to be compromised. However, breast cancer incidence rates are significantly reduced after BRRM compared with imaging surveillance, which may be important information for women with pv<i>BRCA</i><i>1/2</i> considering BRRM.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2026-02-04
DOI
https://doi.org/10.1200/jco-25-00834
Primary Topic
BRCA gene mutations in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Survival Outcomes With or Without Risk-Reducing Mastectomy in BRCA1 and BRCA2 Pathogenic Variant Carriers

N. Flaum, F. Lalloo, James A. Harvey, S. Howell et al.
Journal of Clinical Oncology
BRCA gene mutations in cancer
article

Survival Outcomes With or Without Risk-Reducing Mastectomy in BRCA1 and BRCA2 Pathogenic Variant Carriers

N. Flaum, F. Lalloo, James A. Harvey, S. Howell, Ashu Gandhi, D. Gareth Evans, Lyndsey Highton, Emma Woodward, Claire Forde, Elaine F. Harkness
article en

Abstract

For women electing imaging surveillance over risk-reducing surgery, our results may offer reassurance that their breast cancer-specific survival and OS are unlikely to be compromised. However, breast cancer incidence rates are significantly reduced after BRRM compared with imaging surveillance, which may be important information for women with pv<i>BRCA</i><i>1/2</i> considering BRRM.

Journal of Clinical OncologyVol. 44(10)
Manchester Academic Health Science Centre (GB), University of Manchester (GB), Manchester University NHS Foundation Trust (GB), Cancer Research UK Manchester Institute (GB), The Christie NHS Foundation Trust (GB)
Gender equality
Openalex Percentile: Top 63%
BRCA gene mutations in cancer
DOISourceOpenAlex
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