<i>Salmonella</i> Stanley ST29 carrying IncHI2/ST3- <i>bla</i> <sub>NDM-5</sub> plasmid emerged in a 4-month-old infant with diarrhea
<i>Salmonella</i> serovar Stanley ST29 is an emerging foodborne pathogen with community spread potential, while its carbapenem resistance remains uncommon. In a longitudinal pediatric case with diarrhea, two clonal ST29 isolates sampled 2 months apart revealed within-host evolutionary dynamics: Tn<i>7051</i>-mediated excision of <i>bla</i><sub>NDM-5</sub> from an IncHI2/ST3 plasmid. Moreover, phylogenomics connected the case isolate to strains from a healthy carrier and from food-chain-associated sources in the same region (17-18 SNPs), underscoring community dissemination and the need for One-Health surveillance.
Authors
- Hongmei Mo
- Xiaojuan Gao (ORCID: https://orcid.org/0000-0002-8622-3322)
- Yuman Bai
- Yi-hua Cai
- Ming-Yi Gao
- Zhongpeng Cai (ORCID: https://orcid.org/0000-0002-2540-3215)
- Liquan Lv (ORCID: https://orcid.org/0000-0001-6028-1041)
- Jiayi Liu (ORCID: https://orcid.org/0000-0003-1819-2998)
- Yue Cui (ORCID: https://orcid.org/0000-0002-5939-8717)
Institutions
- Shenzhen Luohu People's Hospital (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1128/aac.01471-25
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00