Contrasted modifications of IgM and IgT repertoires induced by high- and low-virulent infectious pancreatic necrosis virus strains in rainbow trout (Oncorhynchus mykiss)
These findings demonstrate that even minor VP2 variations can profoundly affect not only the magnitude but also the clonal architecture and composition of antiviral B cell responses, highlighting the importance of detailed, strain-specific immune profiling in guiding vaccine development for aquaculture.
Authors
- Luc Jouneau (ORCID: https://orcid.org/0000-0002-5094-7302)
- Amr Ahmed Abdelrahim Gamil (ORCID: https://orcid.org/0000-0001-9920-6487)
- Bertrand Collet
- Vanessa Mhanna
- Sofie Navelsaker Thommessen
- Rosario Castro
- Pierre Boudinot
- Oystein Evensen
- Hetron M. Munang´andu
Institutions
- Inserm (FR)
- Institut Universitaire de France (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris-Saclay (FR)
- Sorbonne Université (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Virologie et Immunologie Moléculaires (FR)
- Immunologie - Immunopathologie - Immunothérapie (FR)
- Norwegian University of Life Sciences (NO)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1690504
- Primary Topic
- Aquaculture disease management and microbiota
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agence Nationale de la Recherche
- Norges Forskningsråd
- Norges Miljø- og Biovitenskapelige Universitet
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement