Antimicrobial performance of amorphous vs. crystalline La1-xSrxCoO3 perovskites

Perovskite materials, with their unique crystal structure and chemical properties, are emerging as promising antimicrobial agents for potential biomedical applications. In this research, different weight percentages of Sr 2 + doped amorphous and crystalline Lanthanum Cobaltite (La 1-x Sr x CoO 3 defined as LSCO) (x = 0, 0.025, 0.05, 0.1, and 0.15) perovskite was synthesized by using a simple combination of sol-gel and molten-salt processes and characterized by X-ray diffraction (XRD), and scanning electron microscopy (SEM) ensures the uniform morphology of the materials. During antimicrobial study using the Kirby Bauer method, amorphous LSCO showed much better activity than crystalline LSCO against Escherichia coli , Vibrio cholerae , and Bacillus subtilis species. Particularly, the 5 % Sr 2+ doped LSCO showed the best performance against Vibrio cholerae, with a 10.44 % increase in the inhibition zone when compared to the undoped LSCO . Furthermore, the 2.5 % Sr 2+ doped LSCO increased the inhibition zone by 14.03 % against Escherichia coli. However, it is interesting to note that the introduction of doping resulted in a decline in antibacterial effectiveness for Bacillus subtilis . Ultimately, the largest inhibition zone of 54.5 ± 1.8 mm was recorded against Vibrio cholerae , specifically for La 0.95 Sr 0.05 CoO 3 . These findings clearly highlight the significant impact of Sr²⁺ doping on the antimicrobial properties of LSCO, demonstrating its potential as a valuable material for antibacterial applications. • Perovskites are promising antimicrobial nanomaterials. • Sr²⁺ doped amorphous and crystalline LSCO were developed. • Amorphous LSCO showed superior antimicrobial activity. • La₀.₉₅Sr₀.₀₅CoO₃ reached a 54.50 mm inhibition zone. • Sr²⁺ doping significantly enhanced antibacterial behavior.