SK channel upregulation and sex-specific mechanisms drive spinal motoneuron reduced excitability with age
These findings reveal sex-specific aging mechanisms in motoneurons, explain women's higher frailty risk, and identify novel drug targets to counteract age-related muscle weakness and neuromuscular decline in older adults.
Authors
- Sherif M. Elbasiouny (ORCID: https://orcid.org/0000-0002-6227-3894)
- Teresa L. Garrett
- Weston Gelford
- K Pereira Gerber
- Ibrahim Abdul Halim
- Mohamed H. Mousa (ORCID: https://orcid.org/0000-0002-6584-3792)
- Cierra L. Ellington
Institutions
- Wright State University (US)
- Human Factors (Norway) (NO)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fnagi.2026.1687226
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00