Side versus adverse effects of elexacaftor/tezacaftor/ivacaftor therapy in people with CF

ETI demonstrates robust real-world efficacy in adults with CF. Side effects due to CFTR restoration are generally self-limiting, whereas adverse effects from drug toxicity persist longer and are more frequently cause for permanent discontinuation of ETI.

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Publication Details

Journal
Respiratory Medicine
Published
2026-02-04
DOI
https://doi.org/10.1016/j.rmed.2026.108697
Primary Topic
Cystic Fibrosis Research Advances
Type
article
Field-Weighted Citation Impact
0.00
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article

Side versus adverse effects of elexacaftor/tezacaftor/ivacaftor therapy in people with CF

E.C. van der Hout, J.B.A. Gorgels, H.G.M. Heijerman, I. Bronsveld et al.
Respiratory Medicine
Cystic Fibrosis Research Advances
article

Side versus adverse effects of elexacaftor/tezacaftor/ivacaftor therapy in people with CF

E.C. van der Hout, J.B.A. Gorgels, H.G.M. Heijerman, I. Bronsveld, R.W. Hofland, J. Koopman
article en

Abstract

ETI demonstrates robust real-world efficacy in adults with CF. Side effects due to CFTR restoration are generally self-limiting, whereas adverse effects from drug toxicity persist longer and are more frequently cause for permanent discontinuation of ETI.

Respiratory MedicineVol. 253
University Medical Center Utrecht (NL)
Openalex Percentile: Top 68%
Cystic Fibrosis Research Advances
DOIOpen Access PDFOpenAlex
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Side versus adverse effects of elexacaftor/tezacaftor/ivacaftor therapy in people with CF — E.C. van der Hout, J.B.A. Gorgels, et al. · Respiratory Medicine (2026) | TGRS Research Map | TGRS