Mosquito direct skin feeding bioassay: 15 years of experience and a standardised approach in Mali

The DSF bioassay is a xenodiagnostic tool to detect transmissible malaria parasites, and a scalable and safe method for evaluating TBV efficacy. DSF offers several advantages including close mimicry of naturally occurring transmission, simplicity of performance and standardisation, and scalable throughput to support late-stage vaccine trials. While parasite transmission rates measured by DSF were low overall at study sites in Mali, sufficient transmission endpoints are generated to assess efficacy of interventions that interrupt transmission, supporting the DSF bioassay as a surrogate efficacy endpoint for TBV studies.

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Publication Details

Journal
Malaria Journal
Published
2026-02-04
DOI
https://doi.org/10.1186/s12936-025-05726-7
Primary Topic
Malaria Research and Control
Type
article
Field-Weighted Citation Impact
0.00
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article

Mosquito direct skin feeding bioassay: 15 years of experience and a standardised approach in Mali

Bourama Kamaté, Heather Goodman, Cheick Sékou F. Traore, Sekou Goita et al.
Malaria Journal
Malaria Research and Control
article

Mosquito direct skin feeding bioassay: 15 years of experience and a standardised approach in Mali

Bourama Kamaté, Heather Goodman, Cheick Sékou F. Traore, Sekou Goita, Amatigué Zéguimé, Lakamy Sylla, A Traore, Freda Omaswa, Kourane Sissoko, Moussa Diallo, Jennifer Kwan, Alemush Imeru, Seydou Sankare, Agnès Guindo, Adama Moussa Sacko, Mariam Doumbia, Yacouba Dembele, Olga Muratova, Abdoulaye Katilé, Emily Higbee, Mamady Koné, Daman Sylla, Boubacar Tembely, Sara A Healy, Alpha Seydou Yaro, Issaka Sagara, Abdrahamane Fofana, Sadio D. K. Diarra, Salifou M. Kone, Moridie Sidibe, Boubacar Coulibaly, Ogobara K. Doumbo, Sale Sidibe, M.’bouye Doucoure, Patrick E. Duffy, Ousmane A. Poudiougo, Ibrahima Baber, Jen C. C. Hume, Mamadou B. Coulibaly, Bakary Traore, Mahamadoun H. Assadou Maiga, Yimin Wu, Yacouba Diarra, Baba Djiguiba
article en

Abstract

The DSF bioassay is a xenodiagnostic tool to detect transmissible malaria parasites, and a scalable and safe method for evaluating TBV efficacy. DSF offers several advantages including close mimicry of naturally occurring transmission, simplicity of performance and standardisation, and scalable throughput to support late-stage vaccine trials. While parasite transmission rates measured by DSF were low overall at study sites in Mali, sufficient transmission endpoints are generated to assess efficacy of interventions that interrupt transmission, supporting the DSF bioassay as a surrogate efficacy endpoint for TBV studies.

Malaria JournalVol. 25(1)
National Institutes of Health (US), Université des Sciences, des Techniques et des Technologies de Bamako (ML), National Institute of Allergy and Infectious Diseases (US)
Industry, innovation and infrastructure
Openalex Percentile: Top 68%
Malaria Research and Control
DOIOpen Access PDFOpenAlex
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