Risk factors for adverse events following rabies vaccination: a multivariate analysis of real-world data

This study is the first to identify bilateral deltoid vaccination as an independent risk factor for adverse reactions to rabies vaccine. The constructed nomogram model demonstrates high accuracy in identifying high-risk individuals. Clinically, it is recommended that high-risk exposure patients receive single-site vaccination combined with a 4-dose regimen, with wound management completed within 24 h. Enhanced monitoring is advised for hypertensive patients to mitigate potential risks.

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Publication Details

Journal
Frontiers in Public Health
Published
2026-02-04
DOI
https://doi.org/10.3389/fpubh.2026.1721524
Primary Topic
Rabies epidemiology and control
Type
article
Field-Weighted Citation Impact
0.00
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article

Risk factors for adverse events following rabies vaccination: a multivariate analysis of real-world data

Hao Xu, Qiye Ma, Wenjie Yan
Frontiers in Public Health
Rabies epidemiology and control
article

Risk factors for adverse events following rabies vaccination: a multivariate analysis of real-world data

Hao Xu, Qiye Ma, Wenjie Yan
article en

Abstract

This study is the first to identify bilateral deltoid vaccination as an independent risk factor for adverse reactions to rabies vaccine. The constructed nomogram model demonstrates high accuracy in identifying high-risk individuals. Clinically, it is recommended that high-risk exposure patients receive single-site vaccination combined with a 4-dose regimen, with wound management completed within 24 h. Enhanced monitoring is advised for hypertensive patients to mitigate potential risks.

Frontiers in Public HealthVol. 14
Integrated Chinese Medicine (China) (HK), Ningbo No. 2 Hospital (CN), Ningbo No.6 Hospital (CN)
Reduced inequalities
Openalex Percentile: Top 67%
Rabies epidemiology and control
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