Indole‐Based π‐Extended Monophosphine Ligands for Enhanced Palladium‐Catalyzed Sonogashira Coupling
ABSTRACT A general palladium‐catalyzed Sonogashira cross‐coupling reaction of aryl and heteroaryl chlorides with aliphatic, aryl and heteroaryl alkynes is described. The Pd(dba)₂/ PCy 2 ‐Napdole‐phos catalyst system efficiently promotes the reaction, exhibiting broad substrate scope and excellent functional group tolerance. Notably, the catalyst loading can be down to 0.2 mol% Pd. The PCy 2 ‐Napdole‐phos , featuring an extended π‐system provides substantial steric bulk to facilitate the construction of C(sp 2 )—C(sp) bonds.
Authors
- Cheuk Long Li
- H. M. CHANG
- Man Ho Tse
- Yu Kiu Lau
- Raymond Wai‐Yin Sun
- Chun Pong Hui
- Ho Kwan Lou
- Iat In Chan
- Fuk Yee Kwong
- Pui Ying Choy
Institutions
- Chinese University of Hong Kong (HK)
- State Key Laboratory of Synthetic Chemistry (CN)
- Guangzhou Electronic Technology (China) (CN)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1002/jhet.70151
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Innovation and Technology Commission
- Chinese University of Hong Kong
- Basic and Applied Basic Research Foundation of Guangdong Province